Anicell Regenerative Therapies

At Walking Paws Rehab we offer options for regenerative therapies. We work closely with Anicell to provide stem cell therapies for our patients. Our stem cell and amniotic injections don’t require surgery or anesthesia. Your pet can receive stem cells in the comfort of our treatment room while you are present!

Anicell is an injectable regenerative material that is made from amnion. Amnion is the innermost membrane and surrounding fluid that aids in growth of a fetus in the womb. This material is rich in all the basic building blocks of tissue and bone including stem cells, collagen, growth factors, hyaluronic acid, carbohydrates, laminin and proteins. Amnion is immune privileged, meaning it should not invoke an immune response from the body. By injecting amnion near injured tissue or joints, we can help jumpstart the healing process. Amnion is collected non-invasively during birth without any harm to the mother or puppies. There are two products we use from anicell. The differences are listed below:

  • Animotion: Animotion is the amnion product that includes stem cells. This is indicated for tendon and ligament injuries or dogs with arthritis who are over 8 years of age.
  • Animatrix: Animatrix does not contain stem cells, but has all the other building blocks for healthy tissue listed above. This is indicated for dogs with arthritis who are less than 8 years of age.


  • Partial cranial cruciate tears
  • Osteoarthritis
  • Hip and Elbow Dysplasia
  • Tendinopathies
  • Carpal hyperextension injuries
  •  Achilles injuries

Advantages of Anicell

A non-invasive procedure that does not require painful harvesting of bone marrow or fat. No sedation or anesthetics required.
Amniotic material is regenerative fetal components safely collected during parturition versus culturing aged adult cells. It includes the basic building blocks of the ECM such as collagens, carbohydrates, lipids, hyaluronic acid, laminin, fibronectin and other complex growth factors. These materials form the basis of a covering that is biocompatible with the wound tissue and protects it from the outside environment.
Amnion is immune privileged — it lacks the MHC Type II expressions (blood antigens) that would normally elicit an inflammatory immune response commonly referred to as rejection.
No collection kit shipping required for fat or bone marrow samples. No culturing or lab work needed.
We are able to administer immediately in the field during the acute inflammatory signaling phase.

Learn More About Anicell

Anicell is given as a subcutaneous injection near the site of injury. This means we don’t have to inject into the joint, resulting in a comfortable and low risk procedure. Though the risks are low, any time we break through the skin there is always risk of infection, swelling, or an immune reaction. The area will be shaved and cleaned prior to injection. For dogs who are calm and okay with handling no sedation is required. For dogs who are more reactive we may recommend oral sedation to help make the procedure less stressful for your dog.

Most dogs have no significant side effects after their injection. Some dogs will experience swelling at the site of injection and soreness after the injection. We recommend walking or gentle range of motion to help direct blood flow to the area. Please do not give anti-inflammatory medication or ice the area after injection as this will diminish the inflammatory response that we want. If your dog is painful after the injection, we can prescribe other pain medications.

We want to encourage low impact activity after anicell injections. If this is an acute injury, we recommend crate rest for 48 hours after the injection followed by progressive activity. For more chronic issues, we recommend allowing activity right away. Your therapist will give you recommendations for specific activities for your pet based on their needs.

Modalities that promote blood flow to an area can be used in conjunction with Anicell. This may include shockwave, laser, or ultrasound. Which modalities we use will depend on your pet and their specific needs.

Unless your veterinarian directs you otherwise, please stop anti-inflammatories. The anicell works by traveling to active areas of inflammation. Anti-inflammatories include prescriptions such as carprofen/rimadyl/truprofen, galliprant, deramaxx, previcox, and prednisone. If your dog is on prednisone please speak to your therapists prior to injection as for some patients it is not safe to stop prednisone or discontinue abruptly. Anti-inflammatories also include supplements such as dasuquin advanced and microlactin. The goal is that anicell will improve the pain and chronic inflammation so that prescription anti-inflammatories are no longer needed or at a lower dose. If still needed, anti-inflammatories can be restarted 6 weeks after injection.

Every dog responds differently to anicell. Some dogs will show immediate improvements in the first 2 weeks. Other dogs will slowly improve over the course of 6-12 weeks. Sometimes dogs don’t respond to the first injection. This is usually because there is another area of the body that has more inflammation. The anicell works on the part of the body that has the most active inflammation. In these cases, anicell will provide a free second injection for your pet. Anicell can be a great tool to use in conjunction with our other interventions and can help your dog get back to their normal activities.

Let's Get Your Pet Back On Their Paws!

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